About this Course
4.7
637 ratings
147 reviews
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100% online

Start instantly and learn at your own schedule.
Flexible deadlines

Flexible deadlines

Reset deadlines in accordance to your schedule.
Hours to complete

Approx. 13 hours to complete

Suggested: 12-18 hours videos and labs...
Available languages

English

Subtitles: English...

Skills you will gain

Genetic AnalysisBioinformatics AnalysisEvolutionComparative Genomics
100% online

100% online

Start instantly and learn at your own schedule.
Flexible deadlines

Flexible deadlines

Reset deadlines in accordance to your schedule.
Hours to complete

Approx. 13 hours to complete

Suggested: 12-18 hours videos and labs...
Available languages

English

Subtitles: English...

Syllabus - What you will learn from this course

Week
1
Hours to complete
3 hours to complete

NCBI/Blast I

In this module we'll be exploring the amazing resources available at NCBI, the National Centre for Biotechnology Information, run by the National Library of Medicine in the USA. We'll also be doing a Blast search to find similar sequences in the enormous NR sequence database. We can use similar sequences to infer homology, which is the primary predictor of gene or protein function. ...
Reading
4 videos (Total 52 min), 4 readings, 1 quiz
Video4 videos
Lecture25m
Lab Discussion24m
Summarym
Reading4 readings
Acknowledgements10m
Course Logistics10m
Lecture Materials10m
Lab 1 -- Exploring NCBI30m
Quiz1 practice exercise
Lab 1 Quiz6m
Week
2
Hours to complete
3 hours to complete

Blast II/Comparative Genomics

In this module we'll continue exploring the incredible resources available at NCBI, the National Centre for Biotechnology Information. We will be performing several different kinds of Blast searches: BlastP, PSI-Blast, and Translated Blast. We can use similar sequences identified by such methods to infer homology, which is the primary predictor of gene or protein function. We'll also be comparing parts of the genomes of a couple of different species, to see how similar they are....
Reading
4 videos (Total 58 min), 2 readings, 1 quiz
Video4 videos
Lecture32m
Lab Discussion23m
Summarym
Reading2 readings
Lecture Materials10m
Lab 2 -- Advanced Blast and Comparative Genomics30m
Quiz1 practice exercise
Lab 2 Quiz6m
Week
3
Hours to complete
2 hours to complete

Multiple Sequence Alignments

In this module we'll be doing multiple sequence alignments with Clustal (as implemented in MEGA), DiAlign, and MAFFT. Multiple sequences alignments can tell you where in a sequence the conserved and variable regions are, which is important for understanding the biology of the sequences under investigation. It also has practical applications, such as being able to design PCR primers that will amplify sequences from a number of different species, for example....
Reading
4 videos (Total 42 min), 2 readings, 1 quiz
Video4 videos
Lecture23m
Lab Discussion16m
Summarym
Reading2 readings
Lecture Materials10m
Lab 3 -- Multiple Sequence Alignment30m
Quiz1 practice exercise
Lab 3 Quiz6m
Week
4
Hours to complete
10 minutes to complete

Review: NCBI/Blast I, Blast II/Comparative Genetics, and Multiple Sequence Alignments

...
Reading
1 quiz
Quiz1 practice exercise
Quiz: Modules 1-310m
4.7
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Top Reviews

By EDApr 27th 2017

Great course. All lectures provide a biological context for the tools you learn in the labs. The labs themselves provide a great introduction to the many tools available for bioinformatic analysis.

By RGNov 5th 2017

I enjoyed doing the course. It is exciting to see how much one can learn from a few gene or protein sequences. Thank you for making the course understandable to a beginner in bioinformatics!

Instructor

Avatar

Nicholas James Provart

Professor
Cell & Systems Biology

About University of Toronto

Established in 1827, the University of Toronto is one of the world’s leading universities, renowned for its excellence in teaching, research, innovation and entrepreneurship, as well as its impact on economic prosperity and social well-being around the globe. ...

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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