About this Course
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Beginner Level

Approx. 13 hours to complete

Suggested: 12-18 hours videos and labs...

English

Subtitles: English

Skills you will gain

Genetic AnalysisBioinformatics AnalysisEvolutionComparative Genomics

100% online

Start instantly and learn at your own schedule.

Flexible deadlines

Reset deadlines in accordance to your schedule.

Beginner Level

Approx. 13 hours to complete

Suggested: 12-18 hours videos and labs...

English

Subtitles: English

Syllabus - What you will learn from this course

Week
1
3 hours to complete

NCBI/Blast I

In this module we'll be exploring the amazing resources available at NCBI, the National Centre for Biotechnology Information, run by the National Library of Medicine in the USA. We'll also be doing a Blast search to find similar sequences in the enormous NR sequence database. We can use similar sequences to infer homology, which is the primary predictor of gene or protein function.

...
4 videos (Total 52 min), 4 readings, 1 quiz
4 videos
Summary
4 readings
Acknowledgements10m
Course Logistics10m
Lecture Materials10m
Lab 1 -- Exploring NCBI1h 30m
1 practice exercise
Lab 1 Quiz6m
Week
2
3 hours to complete

Blast II/Comparative Genomics

In this module we'll continue exploring the incredible resources available at NCBI, the National Centre for Biotechnology Information. We will be performing several different kinds of Blast searches: BlastP, PSI-Blast, and Translated Blast. We can use similar sequences identified by such methods to infer homology, which is the primary predictor of gene or protein function. We'll also be comparing parts of the genomes of a couple of different species, to see how similar they are.

...
4 videos (Total 58 min), 2 readings, 1 quiz
4 videos
Summary
2 readings
Lecture Materials10m
Lab 2 -- Advanced Blast and Comparative Genomics1h 30m
1 practice exercise
Lab 2 Quiz6m
Week
3
2 hours to complete

Multiple Sequence Alignments

In this module we'll be doing multiple sequence alignments with Clustal (as implemented in MEGA), DiAlign, and MAFFT. Multiple sequences alignments can tell you where in a sequence the conserved and variable regions are, which is important for understanding the biology of the sequences under investigation. It also has practical applications, such as being able to design PCR primers that will amplify sequences from a number of different species, for example.

...
4 videos (Total 42 min), 2 readings, 1 quiz
4 videos
Summary
2 readings
Lecture Materials10m
Lab 3 -- Multiple Sequence Alignment1h 30m
1 practice exercise
Lab 3 Quiz6m
Week
4
10 minutes to complete

Review: NCBI/Blast I, Blast II/Comparative Genetics, and Multiple Sequence Alignments

...
1 quiz
1 practice exercise
Quiz: Modules 1-310m
4.7
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Top reviews from Bioinformatic Methods I

By EDApr 27th 2017

Great course. All lectures provide a biological context for the tools you learn in the labs. The labs themselves provide a great introduction to the many tools available for bioinformatic analysis.

By FJFeb 6th 2017

The videos were very clear on how to use various bioinformatic tools. I found no difficulty in understanding them. Really enjoyed the course. Looking forward to the next part of this course!

Instructor

Avatar

Nicholas James Provart

Professor
Cell & Systems Biology

About University of Toronto

Established in 1827, the University of Toronto is one of the world’s leading universities, renowned for its excellence in teaching, research, innovation and entrepreneurship, as well as its impact on economic prosperity and social well-being around the globe. ...

Frequently Asked Questions

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  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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