About this Course
4.7
100 ratings
27 reviews
A big welcome to “Bioinformatics: Introduction and Methods” from Peking University! In this MOOC you will become familiar with the concepts and computational methods in the exciting interdisciplinary field of bioinformatics and their applications in biology, the knowledge and skills in bioinformatics you acquired will help you in your future study and research. Course materials are available under the CC BY-NC-SA License....
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Flexible deadlines

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Clock

Suggested: 1-2 hours/week

Approx. 18 hours to complete
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English

Subtitles: English
Globe

100% online courses

Start instantly and learn at your own schedule.
Calendar

Flexible deadlines

Reset deadlines in accordance to your schedule.
Clock

Suggested: 1-2 hours/week

Approx. 18 hours to complete
Comment Dots

English

Subtitles: English

Syllabus - What you will learn from this course

1

Section
Clock
2 hours to complete

Introduction and History of Bioinformatics

Welcome to “Bioinformatics: Introduction and Methods! Upon completion of this module you will be able to: become familiar with the essential concepts of bioinformatics; explore the history of this young area; experience how rapidly bioinformatics is growing. Our supplementary materials will give you a better understanding of the course lectures through they are not required in quizzes or exams...
Reading
4 videos (Total 69 min), 2 readings, 1 quiz
Video4 videos
History of Bioinformatics30m
Bioinformatics in Mainland China8m
About This Course9m
Reading2 readings
Readings10m
Slides10m
Quiz1 practice exercise
Introduction and History of Bioinformatics20m

2

Section
Clock
2 hours to complete

Sequence Alignment

Upon completion of this module, you will be able to: describe dynamic programming based sequence alignment algorithms; differentiate between the Needleman-Wunsch algorithm for global alignment and the Smith-Waterman algorithm for local alignment; examine the principles behind gap penalty and time complexity calculation which is crucial for you to apply current bioinformatic tools in your research; experience the discovery of Smith-Waterman algorithm with Dr. Michael Waterman himself....
Reading
7 videos (Total 99 min), 2 readings, 1 quiz
Video7 videos
Global Alignment by Dynamic Programming14m
From Global to Local6m
Alignment with Affine Gap Penalty and Calculation of Time Complexity of The Needleman-Wunsch Algorithm6m
Interview with M. S. Waterman Waterman29m
Supplement on Homology & Similarity, Similarity Matrix and Dot Matrix (English Subtitles)10m
Student Presentation (English Subtitles)18m
Reading2 readings
Readings10m
Slides10m
Quiz1 practice exercise
Sequence Alignment18m

3

Section
Clock
1 hour to complete

Sequence Database Search

Upon completion of this module, you will be able to: become familiar with sequence databse search and most common databases; explore the algoritm behind BLAST and the evaluation of BLAST results; ajdust BLAST parameters base on your own research project....
Reading
3 videos (Total 41 min), 2 readings, 1 quiz
Video3 videos
BLAST Algorithm: A Primer13m
Student Presentation (English Subtitles)15m
Reading2 readings
Readings10m
Slides10m
Quiz1 practice exercise
Sequence Database Search10m

4

Section
Clock
1 hour to complete

Markov Model

Upon completion of this module, you will be able to: recognize state transitions, Markov chain and Markov models; create a hidden Markov model by yourself; make predictuions in a real biological problem with hidden Markov model....
Reading
4 videos (Total 47 min), 2 readings, 1 quiz
Video4 videos
Hidden Markov Model11m
Predict with Hidden Markov Model10m
Student Presentation16m
Reading2 readings
Readings10m
Slides10m
Quiz1 practice exercise
Markov Model 14m

Instructors

Ge Gao 高歌, Ph.D.

Assistant Professor, Principle Investigator
Center for Bioinformatics, School of Life Science

Liping Wei 魏丽萍, Ph.D.

Professor, Director
Center for Bioinformatics, School of Life Sciences

About Peking University

Peking University is determined to make its education openly accessible to students in China and around the world. With over 3000 faculty members, Peking University offers excellence in teaching and learning. Founded in 1898, Peking University (PKU) was the first national comprehensive university in China. For the past 115 years, with its hundreds of thousands of outstanding alumni, Peking University has made prominent contributions in the humanities and sciences to further China's prosperity and progress....

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

More questions? Visit the Learner Help Center.