About this Course
4.8
481 ratings
109 reviews
100% online

100% online

Start instantly and learn at your own schedule.
Flexible deadlines

Flexible deadlines

Reset deadlines in accordance to your schedule.
Beginner Level

Beginner Level

Hours to complete

Approx. 8 hours to complete

Suggested: 3 weeks, 1.5 hours per week...
Available languages

English

Subtitles: English...

Skills you will gain

CancerMolecular BiologyCancer BiologyCancer Stem Cells
100% online

100% online

Start instantly and learn at your own schedule.
Flexible deadlines

Flexible deadlines

Reset deadlines in accordance to your schedule.
Beginner Level

Beginner Level

Hours to complete

Approx. 8 hours to complete

Suggested: 3 weeks, 1.5 hours per week...
Available languages

English

Subtitles: English...

Syllabus - What you will learn from this course

Week
1
Hours to complete
1 hour to complete

History and Overview of Metastasis

In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis. ...
Reading
5 videos (Total 18 min), 1 quiz
Video5 videos
Introduction to History and Overview of Metastasism
History and Overview of Metastasis4m
History of Metastasis Theory4m
Introduction to the Sequential Steps of Metastasis5m
Quiz1 practice exercise
History and Overview of Metastasis20m
Hours to complete
1 hour to complete

Primary Tumor Growth and Neoangiogenesis

In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types. ...
Reading
5 videos (Total 36 min), 1 quiz
Video5 videos
Tumor formation: Uncontrolled cell division12m
The role of mutations in primary tumor formation and evolution11m
Neoangiogenesis: new blood vessel formation in cancer5m
The primary tumor microenvironment: what else affects primary tumor growth?6m
Quiz1 practice exercise
Primary Tumor Growth and Neoangiogenesis24m
Week
2
Hours to complete
1 hour to complete

EMT / Invasion / Intravasation

During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels....
Reading
4 videos (Total 18 min), 1 quiz
Video4 videos
Epithelial-mesenchymal transition, invasion, and intravision9m
Local Tumor Invasion4m
Intravasation2m
Quiz1 practice exercise
Invasion and Intravasation14m
Hours to complete
1 hour to complete

Survival in the Circulation and Extravasation

We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation. ...
Reading
6 videos (Total 31 min), 1 quiz
Video6 videos
Glossary of Terms2m
The Circulation4m
How cancer cells survive while in circulation4m
Becoming a circulating tumor cell (CTC) and evading immune detection10m
Homing to a new site in the body and extravasation8m
Quiz1 practice exercise
Survival in the Circulation and Extravasation24m
Week
3
Hours to complete
1 hour to complete

Dormancy and Secondary Tumor Growth

In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer. ...
Reading
6 videos (Total 31 min), 1 quiz
Video6 videos
Metastatic homing5m
Evidence for cancer dormancy4m
Cancer dormancy defined8m
Properties of dormant cancer cells6m
Secondary outgrowth4m
Quiz1 practice exercise
Dormancy and Secondary Tumor Growth20m
Hours to complete
1 hour to complete

Morbidity and Mortality Associated with Metastasis

In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people....
Reading
4 videos (Total 27 min), 1 quiz
Video4 videos
Distribution of Metastasis: Where do cancers spread?10m
Cancer Syndromes14m
Congratulations1m
Quiz1 practice exercise
Morbidity and Mortality Associated with Metastasis20m

Instructors

Avatar

Kenneth J. Pienta, M.D.

The Donald S. Coffey Professor of Urology
The James Buchanan Brady Urological Institute
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Jelani Zarif

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
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Sarah Amend

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
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Haley Axelrod

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
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Kenneth Valkenburg

Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

About Johns Hopkins University

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world....

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

More questions? Visit the Learner Help Center.