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Design and Interpretation of Clinical Trials, Johns Hopkins University

4.7
1,225 ratings
220 reviews

About this Course

Clinical trials are experiments designed to evaluate new interventions to prevent or treat disease in humans. The interventions evaluated can be drugs, devices (e.g., hearing aid), surgeries, behavioral interventions (e.g., smoking cessation program), community health programs (e.g. cancer screening programs) or health delivery systems (e.g., special care units for hospital admissions). We consider clinical trials experiments because the investigators rather than the patients or their doctors select the treatment the patients receive. Results from randomized clinical trials are usually considered the highest level of evidence for determining whether a treatment is effective because trials incorporates features to ensure that evaluation of the benefits and risks of treatments are objective and unbiased. The FDA requires that drugs or biologics (e.g., vaccines) are shown to be effective in clinical trials before they can be sold in the US. The course will explain the basic principles for design of randomized clinical trials and how they should be reported. In the first part of the course, students will be introduced to terminology used in clinical trials and the several common designs used for clinical trials, such as parallel and cross-over designs. We will also explain some of the mechanics of clinical trials, like randomization and blinding of treatment. In the second half of the course, we will explain how clinical trials are analyzed and interpreted. Finally, we will review the essential ethical consideration involved in conducting experiments on people....

Top reviews

By AM

Mar 20, 2016

This course is well-designed, well-paced and well-structured. The study examples described in this course really help you understand the importance of design and interpretation of clinical trials.

By TJ

Jun 02, 2018

The instructors have broken down the concepts in a very effective manner and have designed very thoughtful discussion prompts. The course really helped me understand the basics of clinical trials.

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213 Reviews

By Kumar Sanjiv

Feb 10, 2019

its quite good course for overview....

By Paula Cahuina Lope

Feb 09, 2019

Excelente curso muy practico!

By Sixtus Aguree

Jan 31, 2019

A great introductory course in clinical trials; designs and interpretation.

By Alba María Martin Lopez

Jan 30, 2019

This is a really good course if you are starting your journey in a clinical trials. It's really helpful to learn vocabulary related to this field.

By Shafagh Eslami

Jan 16, 2019

It's detailed and well-designed course, which could be helpful for digging into Clinical Trials and how it works!

By Twaib Songoro

Jan 16, 2019

i like this course

By Sarah Roche

Jan 15, 2019

I learned so much from this course. I thought the lectures were very well designed and easy to follow. Thanks Janet and Lea!

By SARA ESTHER CABALLERO CALERO

Jan 05, 2019

This is a very well structured course and great to have a basic and general idea of the main points to verify when either designing or, most importatnt in my case, how to evaluate publications about clinical trials. I would recommend this course for users with at least a minimum scientific background. The videos are engaging, and the reading material supplied (mostly for ethics and reporting) are complete and helps to give depth to what I learned. Congratulations to the organizers. I will definitely take more courses from this University, online, in the future.

By Rahma mostafa

Dec 26, 2018

Excellent course

By Rodrigo Py Gonçalves Barreto

Dec 11, 2018

Amazing course. They discuss basic principles and provide some insights about complex ones too. I'm loving it! Thanks for setting up this course.