About this Course
4.9
1,024 ratings
275 reviews
Medical Neuroscience explores the functional organization and neurophysiology of the human central nervous system, while providing a neurobiological framework for understanding human behavior. In this course, you will discover the organization of the neural systems in the brain and spinal cord that mediate sensation, motivate bodily action, and integrate sensorimotor signals with memory, emotion and related faculties of cognition. The overall goal of this course is to provide the foundation for understanding the impairments of sensation, action and cognition that accompany injury, disease or dysfunction in the central nervous system. The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. This online course is designed to include all of the core concepts in neurophysiology and clinical neuroanatomy that would be presented in most first-year neuroscience courses in schools of medicine. However, there are some topics (e.g., biological psychiatry) and several learning experiences (e.g., hands-on brain dissection) that we provide in the corresponding course offered in the Duke University School of Medicine on campus that we are not attempting to reproduce in Medical Neuroscience online. Nevertheless, our aim is to faithfully present in scope and rigor a medical school caliber course experience. This course comprises six units of content organized into 12 weeks, with an additional week for a comprehensive final exam: - Unit 1 Neuroanatomy (weeks 1-2). This unit covers the surface anatomy of the human brain, its internal structure, and the overall organization of sensory and motor systems in the brainstem and spinal cord. - Unit 2 Neural signaling (weeks 3-4). This unit addresses the fundamental mechanisms of neuronal excitability, signal generation and propagation, synaptic transmission, post synaptic mechanisms of signal integration, and neural plasticity. - Unit 3 Sensory systems (weeks 5-7). Here, you will learn the overall organization and function of the sensory systems that contribute to our sense of self relative to the world around us: somatic sensory systems, proprioception, vision, audition, and balance senses. - Unit 4 Motor systems (weeks 8-9). In this unit, we will examine the organization and function of the brain and spinal mechanisms that govern bodily movement. - Unit 5 Brain Development (week 10). Next, we turn our attention to the neurobiological mechanisms for building the nervous system in embryonic development and in early postnatal life; we will also consider how the brain changes across the lifespan. - Unit 6 Cognition (weeks 11-12). The course concludes with a survey of the association systems of the cerebral hemispheres, with an emphasis on cortical networks that integrate perception, memory and emotion in organizing behavior and planning for the future; we will also consider brain systems for maintaining homeostasis and regulating brain state....
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Advanced Level

Advanced Level

Clock

Suggested: 8 hours/week

Approx. 89 hours to complete
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English

Subtitles: English

Skills you will gain

BrainNeurological DisordersNeurobiologyNeurology
Globe

100% online courses

Start instantly and learn at your own schedule.
Calendar

Flexible deadlines

Reset deadlines in accordance to your schedule.
Advanced Level

Advanced Level

Clock

Suggested: 8 hours/week

Approx. 89 hours to complete
Comment Dots

English

Subtitles: English

Syllabus - What you will learn from this course

1

Section
Clock
2 hours to complete

Getting Started in Medical Neuroscience

<p>Let's get started in Medical Neuroscience! Each module in Medical Neuroscience will begin with a brief description like this that provides you with an overview of the module. In this first module, you will get to know something about Prof. White and his career in neuroscience; you will understand the scope of Medical Neuroscience, its learning resources, your responsibilities for maximizing your benefit in this course, and you will learn Prof. White's tips on how best to study and learn.</p><p> At the end of this module, please take the ungraded preliminary quiz, "Are you ready for Medical Neuroscience", to self-assess your background knowledge. Your score on this quiz will not count toward your overall score in this course. However, you should be able to pass this quiz (score 70% or better) if you are ready for the academic challenge of this course. Students who are likely to achieve their goals in Medical Neuroscience should be able to successfully answer nearly all of the quiz questions on their first attempt and feel comfortable with assessment questions at this level of knowledge.</p>...
Reading
5 videos (Total 75 min), 2 readings, 1 quiz
Video5 videos
The Scope of Medical Neuroscience11m
Learning resources for Medical Neuroscience32m
Your Part!13m
"Neur-run" with Professor White3m
Reading2 readings
Learning Objectives10m
Your Mentor Team10m
Quiz1 practice exercise
Preliminary Quiz: Are you ready for Medical Neuroscience?22m
Clock
2 hours to complete

Neuroanatomy: Introducing the Human Brain

Your introduction to Medical Neuroscience continues as you experience in this module a brief introduction to the human brain, its component cells, and some basic anatomical conventions for finding your way around the human central nervous system....
Reading
4 videos (Total 79 min), 1 reading, 1 quiz
Video4 videos
Functional Microanatomy of Neurons31m
Non-Neural Cells of the CNS20m
Basic Orientation in the Human CNS7m
Reading1 reading
Introduction, Learning Objectives and Recommended Reading10m
Quiz1 practice exercise
Cells of the CNS and Basic Orientation18m

2

Section
Clock
3 hours to complete

Neuroanatomy: Surface Anatomy of the Human CNS

We now begin in earnest our lessons on neuroanatomy with the surface of the human brain, including a brief run through the cranial nerves and the blood supply to the CNS. In this module, you will learn the basic subdivisions of the vertebrate nervous system; however, your focus should be on the cerebral cortex. Along the way, you will be challenged to "build a digital brain" that should help you generate and improve your mental “model” of the cerebral hemispheres of the human brain. Another great way to refine your mental model is through sketching and crafting, so please do the learning objectives that are designed to help you make visible (and tangible) your understanding of the cerebral hemispheres....
Reading
12 videos (Total 129 min), 2 readings, 2 quizzes
Video12 videos
Medial Surface of the Brain5m
Finding the Central Sulcus6m
Ventral Surface of the Brain8m
Building a Digital Brain (Fingers to Gyri)11m
Surface Anatomy of the Brainstem4m
Blood Supply to the Brain15m
Overview of the Cranial Nerves19m
Overview of the Spinal Nerves8m
Localizing the Cranial Nerves13m
Cranial Nerve Function, part 116m
Cranial Nerve Function, part 211m
Reading2 readings
Learning Objectives / Recommended Readings10m
Learning Objectives / Recommended Readings10m
Quiz2 practice exercises
Cerebral Cortex, Brainstem, and Blood Supply24m
Cranial and Spinal Nerves16m
Clock
4 hours to complete

Neuroanatomy: Internal Anatomy of the Human CNS

...
Reading
12 videos (Total 160 min), 2 readings, 2 quizzes
Video12 videos
Cranial Nerve Nuclei, part 112m
Cranial Nerve Nuclei, part 219m
Cranial Nerve Nuclei, part 317m
Cranial Nerve Nuclei, part 417m
Internal Anatomy of the Spinal Cord - Gray and White Matter11m
Internal Anatomy of the Spinal Cord -Longitudinal Organization11m
Internal Anatomy of the Spinal Cord In Cross Sections6m
Ventricles8m
Overview of the Internal Capsule and Deep Gray Matter8m
Localizing the Internal Capsule and Deep Gray Matter In Brain Slabs9m
Localizing the Internal Capsule and Deep Gray Matter In Sylvius Atlases12m
Reading2 readings
Learning Objectives / Recommended Readings10m
Learning Objectives / Recommended Readings10m
Quiz2 practice exercises
Brainstem and Spinal Cord22m
Forebrain26m

3

Section
Clock
3 hours to complete

Neural Signaling: Electrical Excitability and Signal Propagation

We now turn our attention from the tangible (human neuroanatomy) to the physiological as we explore the means by which neurons generate, propagate and communicate electrical signals. After exploring those structures in the human brain that are visible to the unaided eye, we must now sharpen our focus and zoom-in, as it were, to the unitary level of organization and function in the central nervous system: to the level of individual neurons and their component parts that are crucial for neural signaling....
Reading
9 videos (Total 142 min), 1 reading, 1 quiz
Video9 videos
Ionic Basis of the Resting Membrane Potential, part 114m
Ionic Basis of the Resting Membrane Potential, part 215m
Ionic Basis of the Action Potential, part 118m
Ionic Basis of the Action Potential, part 212m
Ionic Basis of the Action Potential, part 315m
Molecular Mechanisms of Action Potential Generation, part 120m
Molecular Mechanisms of Action Potential Generation, part 29m
Propagation of Action Potentials20m
Reading1 reading
Learning Objectives / Recommended Readings10m
Quiz1 practice exercise
Generating and Propagating Electrical Signals20m

4

Section
Clock
5 hours to complete

Neural Signaling: Synaptic Transmission and Synaptic Plasticity

Let’s continue our studies of neural signaling by learning about what happens at synaptic junctions, where the terminal ending of one neuron meets a complementary process of another excitable cell....
Reading
13 videos (Total 226 min), 2 readings, 2 quizzes
Video13 videos
Synaptic Transmission, part 215m
Neurotransmitters, part 115m
Neurotransmitters, part 222m
Ionotropic Neurotransmitters Receptors, part 117m
Ionotropic Neurotransmitters Receptors, part 211m
Metabotropic Neurotransmitters Receptors and Postsynaptic Mechanisms11m
Synaptic Integration25m
Long-Term Potentiation and Depression, part 122m
Long-Term Potentiation and Depression, part 217m
Long-Term Potentiation and Depression, part 314m
Spike-Timing Dependent synaptic Plasticity19m
Hebb's Postulate11m
Reading2 readings
Learning Objectives / Recommended Readings10m
Learning Objectives / Recommended Readings10m
Quiz2 practice exercises
Synaptic Transmission24m
Synaptic Plasticity18m
4.9
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started a new career after completing these courses
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got a tangible career benefit from this course

Top Reviews

By KRDec 22nd 2016

I have not really taken any Neuroscience courses and I have to say this was very challenging with my already full-time load at school but I did it! Yay! I love Dr. White he is an awesome professor!

By RRNov 25th 2016

While I greatly respect Dr. White's obvious immense knowledge of the neural anatomy, I feel taking this course did very little beyond showing me that perhaps medicine and anatomy wasn't for me.

Instructor

Leonard E. White, Ph.D.

Associate Professor
Department of Neurology, Department of Neurobiology, Duke University School of Medicine; Department of Psychology & Neuroscience, Trinity College of Arts & Sciences; Director of Education, Duke Institute for Brain Sciences; Duke University

About Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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