About this Course
4.4
10 ratings
3 reviews
This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences....
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Intermediate Level

Intermediate Level

Clock

Suggested: 6 weeks of study, 3-6 hours per week

Approx. 17 hours to complete
Comment Dots

English

Subtitles: English
Globe

100% online courses

Start instantly and learn at your own schedule.
Calendar

Flexible deadlines

Reset deadlines in accordance to your schedule.
Intermediate Level

Intermediate Level

Clock

Suggested: 6 weeks of study, 3-6 hours per week

Approx. 17 hours to complete
Comment Dots

English

Subtitles: English

Syllabus - What you will learn from this course

1

Section
Clock
3 hours to complete

Module 1

This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c....
Reading
10 videos (Total 121 min), 3 readings, 1 quiz
Video10 videos
Course Introduction16m
Introductionm
Center for Alternatives to Animal Testing4m
Toxicology of the Fifteenth to Twentieth Centuries15m
Toxicology for the Twenty-First Century15m
Historical Perspective17m
The First Report: Toxicity Testing for Assessment of Environmental Agents11m
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22m
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13m
Reading3 readings
useful links20m
supporting reading material10m
Supporting reading material10m
Quiz1 practice exercise
Module 1 Quiz10m

2

Section
Clock
5 hours to complete

Module 2

This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed....
Reading
10 videos (Total 119 min), 4 readings, 2 quizzes
Video10 videos
Adverse Outcome Pathways (AOPs)10m
Exposure-Based Chemical Prioritization13m
ER Bioactivity Model16m
US EPA Endocrine Disruptor Screening Program (EDSP)17m
Modeling of Hazard and Organ Manifestation11m
Building a Signature for Vascular Disruption10m
Testing the Vascular Disruption Signature8m
Virtual Tissue Model: Vascular Development12m
Functional Vascular Development Assays16m
Reading4 readings
Supporting Reading Material10m
Useful links10m
Supporting Reading Material10m
Useful links10m
Quiz1 practice exercise
Module 2 Quiz8m

3

Section
Clock
3 hours to complete

Module 3

This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed....
Reading
11 videos (Total 126 min), 2 readings, 1 quiz
Video11 videos
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology16m
The Concept of the Human Toxome Project21m
Concept and Tool Devlopment11m
Progress7m
Conclusions and Prospectives8m
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?6m
Omics Technologies and High-Throughput Data11m
Interpreting Omics Data11m
PoT Examples and Conclusions15m
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)13m
Reading2 readings
Supporting reading materials10m
Supporting reading material10m
Quiz1 practice exercise
Module 3 Quiz8m

4

Section
Clock
3 hours to complete

Module 4

The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches. ...
Reading
10 videos (Total 115 min), 3 readings, 2 quizzes
Video10 videos
Introduction to Read-Across18m
Good Read-Across Practice21m
Supporting Read-Across with Biological Data12m
Creating a Database of Toxicity12m
Creating an Automated Tool for Read-Across9m
Paradigm Shift in Toxicology7m
2D In Vitro Cell Culture8m
3D In Vitro Cell Cultures8m
Organ-on-a-Chip11m
Reading3 readings
Supporting reading material10m
Supporting reading material10m
Useful links10m
Quiz2 practice exercises
Module 4 Quiz8m
Mid-term exam44m
Clock
1 hour to complete

Module 5

This module will teach you the role of miRNA and epigenetics in toxicology and environmental health. ...
Reading
6 videos (Total 41 min), 1 reading, 1 quiz
Video6 videos
MicroRNA and Epigenetics4m
Epigenetics and Environment6m
MicroRNA: Biogenesis and Functions11m
Role of MicroRNA in Development6m
MicroRNA in Toxicology9m
Reading1 reading
Supporting reading material10m
Quiz1 practice exercise
Module 5 Quiz8m
4.4

Top Reviews

By SMay 4th 2018

Very nicely designed course. The instructors offer an excellent and easy to understand overview of a range of promising Tox21 tools and approaches using good examples and illustrations.

Instructors

Lena Smirnova

Research Associate
Center for Alternatives to Animal Testing

Thomas Hartung

Professor
Environmental Health and Engineering

About Johns Hopkins University

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world....

Frequently Asked Questions

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