About this Course
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Flexible deadlines

Reset deadlines in accordance to your schedule.

Approx. 18 hours to complete

Suggested: 14.5 hours of videos...

English

Subtitles: English

100% online

Start instantly and learn at your own schedule.

Flexible deadlines

Reset deadlines in accordance to your schedule.

Approx. 18 hours to complete

Suggested: 14.5 hours of videos...

English

Subtitles: English

Syllabus - What you will learn from this course

Week
1
1 hour to complete

Welcome

3 videos (Total 19 min), 3 readings
3 readings
Welcome from Professor Jensen10m
About the Instructor10m
Concept Check Questions: Why Electrons?10m
Week
2
3 hours to complete

Currents, Coils, Knobs and Names: Basic anatomy of the electron microscope

9 videos (Total 94 min), 8 readings
9 videos
The Column26m
Sample Chamber14m
Energy Filters7m
Detectors11m
Vacuum Systems9m
Summary and Safety5m
8 readings
Concept Check Questions: Electron Guns10m
Concept Check Questions: Electron Lenses10m
Concept Check Questions: The Column10m
Concept Check Questions: The Sample Chamber10m
Concept Check Questions: Energy Filters10m
Concept Check Questions: Electron Detectors10m
Concept Check Questions: Vacuum Systems10m
Concept Check Questions: Summary and Safety10m
Week
3
3 hours to complete

Fourier Transforms and Reciprocal Space for Beginners

7 videos (Total 134 min), 6 readings
7 videos
2-D Waves and Images19m
2-D Transforms and Filters32m
3-D Waves and Transforms13m
Convolution and Cross-Correlation15m
6 readings
Concept Check Questions: 1-D Sine Waves and Their Sums10m
Concept Check Questions: 1-D Reciprocal Space10m
Concept Check Questions: 2-D Waves and Images10m
Concept Check Questions: 2-D Transforms and Filters10m
Concept Check Questions: 3-D Waves and Transforms10m
Concept Check Questions: Convolution and Cross-correlation10m
Week
4
4 hours to complete

Image Formation

7 videos (Total 164 min), 6 readings
7 videos
The Contrast Transfer Function33m
Defocus and its Effects21m
Envelopes16m
CTF Correction31m
6 readings
Concept Check Questions: Amplitude and Phase Contrast10m
Concept Check Questions: Wave Propagation and Phase Shifts10m
Concept Check Questions: The Contrast Transfer Function10m
Concept Check Questions: Defocus and its Effects10m
Concept Check Questions: Envelopes10m
Concept Check Questions: CTF Correction10m
4.9
42 ReviewsChevron Right

Top reviews from Getting started in cryo-EM

By LRFeb 19th 2018

Great course. I thought it was presented in a very informative way and i learned a lot about cryo-EM. In fact, it made me want to learn more about it. Thank you.

By ALJul 20th 2016

An excellent introduction to the topic, explaining from the basics to the detail of things. Useful and recommended to anyone in structural biology.

Instructor

Avatar

Grant J. Jensen

Professor of Biophysics and Biology; Investigator, Howard Hughes Medical Institute
Biology and Biological Engineering

About Caltech

Caltech is a world-renowned science and engineering research and education institution, where extraordinary faculty and students seek answers to complex questions, discover new knowledge, lead innovation, and transform our future. Caltech's mission is to expand human knowledge and benefit society through research integrated with education. We investigate the most challenging, fundamental problems in science and technology in a singularly collegial, interdisciplinary atmosphere, while educating outstanding students to become creative members of society....

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

More questions? Visit the Learner Help Center.